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The study demonstrates that a deficiency in SMIM1 correlates with a marked reduction in energy expenditure, thereby increasing susceptibility to weight gain and obesity

Registered dietitian Ashley Koff highlights another important consideration: nutrient quality

Sustained treatment for 6+ months produces the most robust reversal of fibrosis markers and hepatic steatosis

As of July 26, 2026, 21 CFR 216.23 lists six substances that can be used through this pathway: Brilliant Blue G, cantharidin for topical use only, diphenylcyclopropenone for topical use only, N-acetyl-D-glucosamine for topical use only, squaric acid dibutyl ester for topical use only, and thymol iodide for topical use only