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(5.1) Recent Major Changes Boxed Warning 6/2026 Warnings and Precautions, Lactic Acidosis (5.1) 6/2026 Indications and Usage for Saxagliptin and Metformin Saxagliptin and metformin hydrochloride extended-release tablets are a combination of saxagliptin, a dipeptidyl peptidase-4 (DPP4) inhibitor, and metformin hydrochloride (HCl), a biguanide, indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus

Changes in resting heart rate with GLP-1 receptor agonists have become an important topic in diabetes and cardiometabolic care

insulin iAUC and tAUC