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Tissue distribution of the novel DPP-4 inhibitor BI 1356 is dominated by saturable binding to its target in rats

The original Diabetology Axcess formulation (chenodeoxycholate and propyl gallate in a 2:1 ratio wt:wt) has been applied in dogs, using a GLP-1 RA which has been modified to resist not only DPP4 attack, but also breakdown by intestinal proteases ( The work reported by others in dogs, as well as our own results reported here in pigs and rats, show that the Axcess formulation is able to deliver GLP-1 receptor agonists in effective amounts, even at low doses, to the intestinal mucosa