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They were still able to secrete somatostatin in response to GLP-1 showing that the delta cells are still functional although with a lower level of basal somatostatin secretion
Research has identified coffee-specific catechols as a contributing factor in coffee-induced gastric acid secretion that persists even in decaffeinated and low-CGA preparations which is why some individuals report stomach sensitivity to coffee even after eliminating caffeine and reducing CGA exposure [ 3 ]
Goldman warns
The authors identified only three published human pilot studies, all small and methodologically limited
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