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The application technique, frequency of use, combination with other active ingredients and number of sessions must be adapted to the professional assessment of each case and to the aesthetic response observed in the treated area

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The largest study to date assessed the use of metformin 1 g, twice daily, in 428 people with type 1 diabetes who were treated for 3 years, with a primary endpoint of changes in mean carotid intimamedia thickness, a marker of cardiovascular disease risk