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N Engl J Med 341 : 785792 Clemmons DR (1993) Use of growth hormone and insulin-like growth factor I in catabolism that is induced by negative energy balance

This precision in dosing is essential for achieving reproducible results and conducting reliable studies into the benefits and side effects of peptide research

Interpretation: Splinting has benefit, but not as much as injection, and is best used in combination with injection Clinical reasoning Splinting - best to include thumb and wrist Reduces thumb abduction and wrist deviation Minimises APL/EPB (1st dorsal compartment) mechanical irritation Best chance of being effective when used during sleep as well as waking hours Activity modification Much easier conceptually than practically