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What the Probiotic Constipation Literature Actually Shows The probiotic literature on functional constipation is the closest analogous evidence base, with the caveat that GLP-1 constipation has a specific pharmacological driver that functional constipation lacks

J Biol Chem 265:1291612926 Richards EM, Rosenthal RE, Kristian T, Fiskum G (2006) Postischemic hyperoxia reduces hippocampal pyruvate dehydrogenase activity

LY3298176, a dual GIP and GLP-1 receptor agonist: discovery and mechanistic characterization. Cell Metab

Pharmacodynamics: Ipamorelin is a selective ghrelin (GHS-R1a) receptor agonist that stimulates growth hormone release with minimal impact on cortisol, prolactin, or appetite pathways