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Integrated gene and miRNA expression analysis of prostate cancer associated fibroblasts supports a prominent role for interleukin-6 in fibroblast activation

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The Leyden 2002 clinical evaluation in the Journal of Cosmetic Dermatology compared a copper tripeptide cream and serum against placebo in 67 women with photodamaged skin and found significant improvements in wrinkle depth, skin laxity, clarity, and density at 12 weeks [30]