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In animal studies, high-dose heme iron (100 mg/kg) elevated colonic TNF- concentrations 2.8-fold and significantly increased expression of macrophage infiltration marker F4/80 (Wei et al., 2024)

Iron overload and diabetes risk: a shift from glucose to fatty acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis

Key parameters assessed include basal and maximal respiratory capacity, ATP-linked respiration, spare respiratory capacity, basal glycolysis, and glycolytic reserve

"ICER has a budget impact threshold that estimates whether the uptake of a drug can lead to a budget impact concern," he said