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High sugar intake can blunt natural GLP-1 secretion and worsen insulin resistance

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The paper takes advantage of the fact that some patients undergoing gastric bypass (GB) surgery experience significantly increased insulin secretion following a meal, sometimes even resulting in clinically significant hypoglycaemia

These synergy studies established the mechanistic principle underpinning the GHRH analogue + GHS-R1a agonist combination format demonstrating that dual-pathway somatotroph co-stimulation is not merely additive but produces signal amplification through convergent intracellular mechanisms