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These selectivity pharmacology studies have established Ipamorelins pentapeptide structure as the reference pharmacophore solution for achieving GHS-R1a-selective GH release and provided the comparative dataset against which all subsequent selective GH secretagogue compounds are evaluated

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Third, the relatively stable insulin levels on keto, compared to the spikes and crashes of a high-carbohydrate reduced-calorie diet, may provide a more favorable hormonal environment for lean tissue preservation