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Recent findings indicate that organelles containing enzymes for the synthesis of O 2 - and H 2 O 2 can produce OH , which may damage DNA, leading to the development of oxidative DNA adducts

Furthermore, another study indicated that the nephroprotective effect mediated through TLR-2 is in part attributed to activation of autophagy and knockout of TLR2 reduced expression of autophagy proteins and exacerbated renal dysfunction in the CP-induced AKI model (Liang et al., 2017)