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In parallel, glycine, another major component of collagen, is synthesized from serine, which is derived from the glycolytic intermediate 3-phosphoglycerate via the enzymes phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1), and phosphoserine phosphatase (PSPH), and subsequently converted by serine hydroxymethyltransferase 1/2 (SHMT1/2) [17, 18]

"Origin of life: protoribosome forms peptide bonds and links RNA and protein dominated worlds"

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In our study, IFN--activated macrophages suppressed HBV replication in hepatocytes by decreasing HBV RNA, DNA, and cccDNA levels via induction of ISGs such as APOBEC3G, ISG15, and OAS1