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In addition, polymeric poly(styrene-comaleic anhydride) (PSMA)-NPs and conjugated polymer poly[2-methoxy-5-(2-ethylhexoxy)-1,4-styreneyl](PPV) -PSMA-NPs nanoparticles prepared by nanoprecipitation have also been shown to reverse the immunosuppressive TME by reprogramming TAMs, and which can not only specifically target TAMs but also directly inhibit tumor growth by repolarizing TAMs to kill tumor M1 phenotype (60)

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5A), with a 10% drop in body weight for the highest dose, and an 8% reduction with the 10 and 5 nmol/kg doses relative to vehicle-treated PWA mice (Fig