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However, MIRI will still occur during reperfusion (Wu et al., 2021a), increased production of reactive oxygen species (ROS) (Wu et al., 2020), and calcium overload (Wu et al., 2021b), mitochondrial dysfunction (Xu et al., 2019), potentially leading to severe hemodynamic disturbances and endangering patients' lives

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The binding site for GLP-1(9-36) is formed by the upper halves of transmembrane helices 1 (TM1) and 2 (TM2), extracellular loop 1 (ECL1) and the extracellular domain (ECD), with negligible involvement of the residues in TM3, ECL2, TM5, ECL3 and TM7 commonly participate in the hormone recognition of class B1 G protein-coupled receptors ( Figs