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Key variants tested include GLP1R rs6923761, GIPR rs1800437, FTO rs9939609, and MC4R rs17782313each influencing appetite regulation and energy expenditure

Some studies suggest that CTR and GLP-1 receptors seem to overlap in the nucleus tractus solitarius

176,177,178 Notably, in individuals of European ancestry, the genetic control of SLC2A9a and SLC2A9b isoforms, situated at basolateral and apical membranes respectively, constitutes a prominent genetic signal

Reducing dose of insulin secretagogue or insulin may be necessary Acute Kidney Injury: Monitor renal function in patients with renal impairment reporting severe adverse gastrointestinal reactions Hypersensitivity Reactions: Serious hypersensitivity reactions (e.g., anaphylaxis and angioedema) have been reported