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Substantial Weight Loss Over 68 Weeks Participants who received the highest dose (12 mg) experienced an average 28.7 % reduction in body weight, equivalent to roughly 71.2 lbs from their starting weights over 68 weeks, far greater than the placebo group, which saw about a 2.1 % reduction

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The Wegovy pill showed around 16.6% weight loss on average in a late-stage trial, while Lilly's oral drug caused roughly 12.4% on average in a separate study, when analyzing patients who stayed on treatment

In this regard, it is noteworthy that a selective glucagon receptor antagonist increased hepatic fat in patients with T2D 23