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While highly effective for glycemic control and weight reduction, gastrointestinal adverse effects are commonly reported, with constipation rates varying by indication and dosageapproximately 3-9% in diabetes treatment (Ozempic, Rybelsus) and up to 24% in weight management (Wegovy)

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In a cohort study recently published in JAMA Internal Medicine , researchers set out to provide a head-to-head comparison of these medications in a real-world clinical setting, focusing on weight loss outcomes and gastrointestinal adverse events (AEs)