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P21 and PE-22-28: Strong Preclinical, Zero Human Data These peptides represent the most compelling preclinical candidates without human cognitive data

The molecules bind to some receptors, but not enough to trigger the cascade of effects that produce appetite suppression, improved insulin sensitivity, and the metabolic changes that drive weight loss

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However, in individuals with BED, severe nausea or vomiting could potentially trigger or exacerbate disordered eating patterns or lead to nutritional deficiencies if food intake becomes severely restricted