Composite endpoints that include metabolic endpoints, validated psychological measures such as the PHQ-9 for depression, BES or measures of quality of life can better reflect improvements in both physical and mental health [41]
If a patient already has slow stomach emptying, known as gastroparesis, a GLP or GLP/GIP should likely be avoided, as this condition will only worsen when the medication is started, often leading to intolerable side effects
Indeed, in the cardiovascular outcome trial (CVOT) for semaglutide, SUSTAIN 6 a relatively short (two-year) and small (3,297 individuals) preregistration trial (an extensive CVOT in obese individuals without T2DM (SELECT) is expected to complete in 2024) HbA 1c was powerfully and durably reduced
FDA-approved peptides for weight loss include: Wegovy ( semaglutide ) Zepbound ( tirzepatide ) Saxenda (liraglutide) How peptides work for weight loss Peptide medications work for weight loss by mimicking GLP-1, a peptide hormone produced in the gut after eating
