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Additional Regulatory Mechanisms Mitigating NLRP3 in PD Major histocompatibility complex (MHC) antigens and proinflammatory cytokines are produced by activated microglia, which also transform into phagocytic cells

Nonpharmacological (such as diet) and pharmacological (such as vitamin E and acetylcysteine) interventions for CKD patients with signs of increased oxidative stress should be developed and evaluated for efficacy in reducing oxidative stress and improving clinical outcomes in this patient group

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