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Gut Microbiome and Inflammation: In the gut, Berberine modulates the microbial community and reduces permeability, thereby lessening the systemic inflammation often linked to metabolic disorders

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It promotes mucosal immunity by increasing IgA (+) cells and reducing pro-inflammatory cytokines (IL-1, IL-6, TNF-), while enhancing beneficial bacterial genera such as Romboutsia (Brasiel et al., 2025