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The Tokyo Guidelines 2018 stratify severity and timing of intervention: Grade I (mild) can proceed to early laparoscopic cholecystectomy within 72 hours

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A person may wish to contact a doctor if: they experience additional symptoms, such as persistent stomach ache, bloating, constipation, or diarrhea they are losing weight without trying to there is blood present in their stool changes to medication do not bring relief alterations to diet do not bring improvement In these cases, the gas may be due to an infection or an underlying condition that needs treatment