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One significant concern is the potential for treatment discontinuation due to cost, drug shortage, or adverse effects, which can lead to a deterioration in key cardiometabolic parameters, including glycemic control, blood pressure, and cholesterol levels

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The researchers concluded that AOD-9604 represents a promising fat-reducing alternative to growth hormone therapy without its associated metabolic risks, particularly regarding glucose regulation and IGF-1 elevation

Furthermore, to confirm the binding between CRAT 3-UTR and miR-132-5p, a luciferase reporter assay was performed with wild-type or mutated CRAT 3-UTR coupled luciferase reporter (Fig