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More specifically, GLP-1RA can act on adipose-derived stem cells (ADSC) and fibroblasts, that present GLP-1R on their surface

HELA-Exos also proved inhibiting growth in an immunocompetent mouse model and patient-derived organoids, showing a promising application as immunotherapy (Fig

Although, Ihh is a critical modulator that promotes PTHrP expression in the growth plate, our observations on the decreased Ihh expression in the Cart IGF-IR / and TamCar IGF-IR / growth plates, however, support an Ihh-independent negative regulation of PTHrP expression and, perhaps, a direct effect on Ihh expression by IGF-IR signaling (41) (Figure 1)

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