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Ilya Yuffa, president of Lilly USA, said at a Citi conference this month that the company expects to launch orforglipron early in the second quarter of 2026

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Compared with vehicle controls, GLP-1GIPLani yielded more than 5,411 differentially expressed genes (DEGs) in the liver, compared to only 913 and 57 DEGs induced by GLP-1GIP and Lani, respectively (Extended Data Fig