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Isaka Kansai, JP

These findings highlight the urgent need for evidence-based guidance for when GLP-1RAs should be used relative to bariatric surgery in adolescents and young adults, including whether medications are most effective before surgery, after surgery, or as part of combination therapy. Other UTSW researchers who contributed to this study are senior author Sarah Barlow, M.D., M.P.H., Professor of Pediatrics

Therefore, 75 RCTs with 21,806 participants were included in our analysis set (Table S2), while 59 studies with 13,322 patients were obtained for the meta-analysis and NMA

In the monotherapy trial, mean change at week 30 was 3.8 kg with 0.5 mg and 4.7 kg with 1 mg, versus 1.2 kg with placebo