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The lower alpha diversitybut not serum LPS levelsalso correlated with increased intestinal permeability, measured by a plasma lactulose/rhamnose ratio 90 min after ingestion of the sugar solution, which is a less validated way to assess intestinal permeability because this one sampling point does not take into account renal clearance

According to Meyer, the high doses of folic acid were necessary to treat the hematological irregularities in patients with pernicious anemia

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