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Key points: Nevi are benign lesions, but some, at low frequency, can progress to melanoma Approximately 30% of primary melanomas have an identifiable nevus precursor Identical oncogenic mutations in BRAF and NRAS are found in both nevi and melanoma The mechanisms that allow nevus senescence after BRAF and NRAS mutation are unclear Many benign nevi have clinically and histologically atypical features, making clinical diagnosis difficult Clinical and advanced photographic/dermoscopic monitoring of nevi can increase sensitivity of melanoma diagnosis Footnotes Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication

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