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A similar strategy of charge reversal was utilized to trigger the charge reversal of cis-aconityl functionalized nanogel system at low pH and subsequently release DOX that was bind to nanogel surface through electrostatic interactions 152

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On the contrary, Acetyl-CoA is an activator of pyruvate carboxylase, thus promoting the TCA flux or the gluconeogenesis (Pietrocola et al., 2015)

While antioxidants such as superoxide dismutase (SOD), catalase, glutathione peroxidase (GSH-Px), peroxidase, and glutathione reductase (GR) are classified as enzymatic, GSH, vitamin C, urate, bilirubin, albumin, ceruloplasmin, transferrin, and lactoferrin are classified as non-enzymatic [18, 19, 20]