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These insights set the stage for more mechanism-driven therapeutic strategies in subsequent decades 13

In patients treated with semaglutide, median duration of nausea was 8 days, vomiting 2 days, diarrhoea 3 days, and constipation 47 days. Over the 68-week trial period nausea occurred in 43.9% of patients (16.1% placebo)

The suppression of the type I IFN response by ROS is due to oxidation of cysteine 147 of murine stimulator of IFN, an ER membrane protein that mediates the IFN response after cytoplasmic DNA sensing 59,133,134

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