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Similar results were obtained by sulfonylurea treatment of WT islets (Supplemental Figure 5A)

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Residues such as Lys209 and Lys248 are directly pointing towards the CoA molecule in the AlphaFold3 model, suggesting these might take over the acetyl groups from acetyl-CoA acting as nucleophiles upon binding of acetyl-CoA in a potential unproductive conformation before adopting its productive conformation (Figs