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Most evidence is derived from small trials, cell culture studies, and animal models rather than large randomized controlled trials

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Additionally, the aberrant muscularization of distal arterioles and excessive production of reactive oxygen species (ROS) exacerbate disease progression by promoting inflammation, oxidative stress, and cellular proliferation (Freund-Michel et al., 2013

BPC-157 has further been shown to interact with dopaminergic and serotonergic neurotransmitter systems effects that have prompted investigation beyond its initial gastrointestinal context