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the FDA serotonin-syndrome warning from MAO-A inhibition (a real risk with SSRIs, SNRIs, triptans and MAOIs), G6PD haemolysis and industrial-grade purity dangers

Some trials 151 , 152 have demonstrated that metformin use during the first trimester significantly reduced early pregnancy loss, with rates of 10.8% versus 42.2%, 151 and 10% versus 26%, 152 compared with control treatments (e.g., folic acid or no intervention)