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doi: 10.2174/0929867327666200705225821, 164 PourayyoubiB.Rezaei-AshtianiA.JavaheriJ.Ebrahimi MonfaredM.ZamaniF

This explains why Glutathione depletion often accompanies conditions with compromised immunity

Common triggers include these events: (1,2,3) Oral injury during a dental procedure or from brushing too hard, playing sports, or biting your cheek while chewing Sensitivity to sodium lauryl sulfate (an ingredient in some mouthwashes and toothpastes) Hormonal changes during menstruation Nutritional deficiencies Emotional stress Food allergies Family history of canker sores Personal history of a chronic disease (celiac disease, Crohns disease, ulcerative colitis, or a condition that weakens the immune system) Learn More About the Causes and Risk Factors of Canker Sores How Is a Canker Sore Diagnosed