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However, intraorally, hyperpigmentation is more typically a consequence of physiologic, idiopathic sources, neoplasia, medications, high serum concentrations of pituitary adrenocorticotropic hormone (ACTH), postinflammatory changes, and genetic or autoimmune disorders

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290,291 Additionally, Siegwarts team introduced the fifth component, selective organ targeting, to achieve precise and universal extrahepatic-targeted mRNA delivery strategies