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Water enables hydrolytic degradation, and peptides in aqueous solution are much less stable than in their lyophilized form
The cell can become distorted and unstable if it doesn't get enough of the vitamin
Methylation Capacity Second, NNMT inhibition affects cellular methylation capacity: SAM is required for hundreds of methyltransferase reactions throughout the cell, and NNMT's consumption of SAM can deplete this critical resource, while the SAH produced by NNMT is a potent product inhibitor of many methyltransferases
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