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The cholesterol hypothesis for heart disease dates back to the early 1900s when Russian physician Nikolay Anichkov demonstrated that feeding rabbits a high cholesterol diet led to the fatty deposits in coronary arteries that cause heart disease

Some pharmacokinetic studies have examined the lower end of the dose-response curve, but these were conducted to establish appropriate starting doses for titration, not to validate microdosing as a standalone strategy

About one in six children and adolescents, ages 2 to 19, are overweight, according to data from the National Institute of Diabetes and Digestive and Kidney Diseases, and almost one in five children and adolescents in that same age group are categorized as obese

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