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These neuroprotective effects generalized across GLP-1RAs with variable blood-brain barrier (BBB) permeability (attributable to differences in properties such as molecular size, albumin binding 11 , and potentially receptor-mediated transport into the brain) 12 and diverse experimental conditions 7 , including various rodent species and strains, animal models with or without diabetes mellitus, stroke induction methods, treatment doses and regimens (initiating prior to, during, or even 13 days after stroke induction) 8,13 , indicating a robust class effect

C.YanA.ElhadadS.WeitmanE

Other compounds may also be active (see What It Does)