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Hyperglycemia triggers ROS production through multiple pathways, including the polyol pathway, protein kinase C (PKC) activation, and advanced glycation end product (AGE) formation

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doi: 10.3748/wjg.v27.i21.2834 24 NishidaAInoueRInatomiOBambaSNaitoYAndohA

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[2] In addition, it may not only trigger the expression of insulin-like growth factor-1(IGF-1) but may also inhibit the secretion of somatostatin

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