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Candidate molecules should be selected based on robust, reproducible evidence from well-controlled studies that adequately address PAINS concerns and demonstrate target engagement

This article explores the differences between GHK-Cu and GHK Basic, dives into the role of skin peptides in skincare research, and analyzes how each peptide performs across various delivery systems

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The process of selecting papers, data collection as well as the quality assessment was performed independently by two authors (A.S., G.R.), and all disagreements were resolved by the discussion with the third author (R.O)