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Furthermore, incretin-based therapies (GLP-1 receptor agonists and dual agonists such as tirzepatide) improve hepatic steatosis, modulate inflammatory responses, and protect -cell function, illustrating how mechanistic insights can be translated into pharmacological strategies (203205)

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Melatonin activates NRF2, which is considered a defense mechanism against ROS as it controls the expression of a collection of genes involved in antioxidant defenses and inflammatory responses 85,86,87,88