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In renal ischemia/reperfusion (I/R) injury, fucoidan activates the SIRT1/NRF2/HO-1 signaling pathway to reduce oxidative stress-induced apoptosis [72]

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Front Cell Neurosci 9:392 Kennedy S, Lam R, McIntyre R, Tourjman S, Bhat V, Blier P, Hasnain M, Jollant F, Levitt A, MacQueen G, McInerney S, McIntosh D, Milev R, Mller D, Parikh S, Pearson N, Ravindran A, Uher R (2016) Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder