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see Table 1) ( While European guidelines recommend up to 4 g/day for adults, most of the included studies administered pharmacological doses ranging from hundreds to thousands of micrograms

This "metabolic buffering" role helps maintain the CoA/acyl-CoA ratio essential for TCA cycle function [1]

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Animal experiments All mouse experiments were approved by the Institutional Animal Care and Use Committee at Fudan University and Shanghai Institute of Biochemistry and Cell Biology