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Participants were randomized to receive placebo or one of several retatrutide dose levels (1 mg, 4 mg, 8 mg, or 12 mg) administered subcutaneously once weekly for 48 weeks

Through this mechanism, Saxenda: Slows gastric emptying , which prolongs the feeling of fullness after meals Reduces appetite by acting on appetite centres in the hypothalamus Enhances glucose-dependent insulin secretion from pancreatic beta cells Suppresses inappropriate glucagon secretion when blood glucose levels are elevated These combined effects lead to reduced calorie intake and, consequently, weight loss