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In addition to the aforementioned HIV study, Gilead and Merck announced the early shutdown of a Phase 3 study called EVOKE-03 that was evaluating Gileads Trodelvy plus Keytruda compared to Keytruda alone in patients with non-small cell lung cancer that express high levels of the PD-L1 protein

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Downregulated expression of occludin and zonula occludens-1 is related to increased matrix metalloproteinases levels in diabetes in both rats and humans [37,38], and inhibition of matrix metalloproteinase-9 prevents increased leakage in streptozotocin-induced diabetic mice [39]