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Some of the medications that can interact with Wegovy (semaglutide) include antimalarials (chloroquine), other diabetes drugs, aspirin, acetaminophen, blood pressure medications such as angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), calcium channel blockers, diuretics (water pills), certain antibiotics (clarithromycin, amoxicillin), androgens, skeletal muscle relaxants (carisoprodol), HIV medications, antipsychotic drugs, and antiepileptic drugs

Am J Physiol Ren Physiol 308:F1229F1237

By helping patients lose weight, Ozempic reduces the risk of complications such as heart disease, high blood pressure, and type 2 diabetes