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As compared to loop diuretics, SGLT2-i may distinctly regulate the interstitial versus intravascular compartment selectively reducing interstitial oedema, which has been observed in HF and DKD, with minimal change in blood volume

Anyone enrolled in a retatrutide trial who is scheduled for surgery or an invasive procedure should inform both their trial team and their anaesthetist well in advance

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As an investigational triple-agonist, fully understanding its long-term cardiovascular, gastrointestinal, and pancreatic safety profile is essential before it can transition from a research setting to routine clinical practice. Dr