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Material and methods: In these calculations, the enzymes used were glutathione reductase (GR) and glutathione S-transferase (GT)

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Microdosing titration with smaller dose increments Strategy B: Increase dosing frequency with reduced dose size This method involves administering smaller doses more frequently than once per week (e.g., every 34 days), which can help maintain more stable drug levels and potentially reduce side effects caused by peak concentrations