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[127] The FDA cautioned that formulations containing semaglutide sodium or semaglutide acetate had not yet been shown to be safe and effective, and stated that moreover, the FDA does not evaluate compounded drugs for safety and effectiveness

Furthermore, methylation issues can contribute to estrogen dominance , since excess estrogen must be eliminated through our detoxification system

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In patients without diabetes, tirzepatide provided an additional 3.6% weight loss compared to semaglutide, while in patients with diabetes, the percentage change in body weight was not statistically different between the two groups